Top 5 Best Ergonomic Mice for People with Arthritis

With so many choices out there, picking the right takes time.

We looked at reviews, specs, and overall performance to narrow it down.

Our top choice was clear.

1
TECKNET Ergonomic Mouse, Wireless Bluetooth Vertical Mouse, 4800 DPI Optical Tracking, 6 Adjustable DPI, Quiet Clicks, 2.4GHz with USB A Receiver, 12 Months Battery, 6 Buttons, Wide Compatibility
TECKNET Ergonomic Mouse, Wireless Bluetooth Vertical Mouse, 4800 DPI Optical Tracking, 6 Adjustable DPI, Quiet Clicks, 2.4GHz with USB A Receiver, 12 Months...
9.7
Amazon.com
2
DeLUX Wired Vertical Ergonomic Mouse, with 6 Programmable Buttons, 4200DPI, Removable Palm Rest, Reduces Wrist Pain and Carpal Tunnel for Medium Hands (M618XU-White)
DeLUX Wired Vertical Ergonomic Mouse, with 6 Programmable Buttons, 4200DPI, Removable Palm Rest, Reduces Wrist Pain and Carpal Tunnel for Medium Hands...
9.2
Amazon.com
3
memzuoix Wired Mouse, USB Computer Mouse 1400 DPI Mobile Optical Mouse Ergonomic Design Computer Mice with 5FT Cord for Laptop, PC, Desktop, MacBook, 5 Buttons (Black)
memzuoix Wired Mouse, USB Computer Mouse 1400 DPI Mobile Optical Mouse Ergonomic Design Computer Mice with 5FT Cord for Laptop, PC, Desktop, MacBook, 5...
9.2
Amazon.com
4
TECKNET Ergonomic Mouse, Rechargeable Wireless Bluetooth Mouse (BT 5.0/5.0+2.4G), Vertical Mouse with Volume Knob, Quiet Clicks, Cordless Mice 6 Adjustable DPI with USB A Receiver, Wide Compatibility
TECKNET Ergonomic Mouse, Rechargeable Wireless Bluetooth Mouse (BT 5.0/5.0+2.4G), Vertical Mouse with Volume Knob, Quiet Clicks, Cordless Mice 6 Adjustable...
8.6
Amazon.com
5
TECKNET Ergonomic Mouse, 4800 DPI Wireless Vertical Mouse, 5 Adjustable DPI Levels, 6 Buttons, 2.4G Silent Wireless Mouse for Laptop, PC, Chromebook - Pink
TECKNET Ergonomic Mouse, 4800 DPI Wireless Vertical Mouse, 5 Adjustable DPI Levels, 6 Buttons, 2.4G Silent Wireless Mouse for Laptop, PC, Chromebook - Pink
8.3
Amazon.com

Top Pick

This is the product that stood out most — for performance, price, and overall value.

TECKNET Ergonomic Mouse, Wireless Bluetooth Vertical Mouse, 4800 DPI Optical Tracking, 6 Adjustable DPI, Quiet Clicks, 2.4GHz with USB A Receiver, 12 Months...

$26.99 $29.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 19, 2025 12:45 pm

Features

Part Number TK-MS007
Model TK-MS007
Warranty 3 years
Color Black
  • 【Seamless Switching Between Three Devices】The ergonomic mouse features Bluetooth (5.0/3.0) and 2.4GHz USB A modes for connectivity. When connected via Bluetooth, The vertical mouse can effectively reduces the usage of your USB-A port (Bluetooth mode can connect to two devices simultaneously), which is convenient for devices without USB ports. To switch to 2.4GHz mode, simply plug in the USB receiver for quick connection without the need for additional software installation. With just a press of a button, you can easily switch between these two modes, enhancing your work efficiency (Note: The 2.4GHz receiver is built into the bottom of the mouse).
  • 【Higher DPI & 6 Adjustable Levels】This vertical ergonomic mouse is equipped with a high-performance chip and features 6 adjustable DPI levels (4800/3200/2400/1600/1200/800) to meet your daily needs. wireless mouse upgraded technology allows this ergonomic mouse to operate smoothly on different types of surfaces. When changing the DPI, the light will flash, with the number of flashes corresponding to the DPI level.
  • 【Silent Mouse】This computer mouse operates quietly, allowing for usage even in quiet environments like libraries. Additionally, the vertical mouse provides nearly silent clicks, helping avoid disturbances to others and ensuring your work or study remains undisturbed (Note: Only the left and right click buttons of the mouse are silent; other function buttons are not silent).
  • 【Ergonomic Design】The wireless mouse's ergonomic design offers ultimate comfort by placing your palm at a near-vertical angle on the desktop, reducing pressure and pain on your wrist caused by prolonged inverted mouse usage (Note: Mouse is designed for right-handed use only).
  • 【Broad Compatibility and Low Battery Warning】The wireless computer mouse is compatible with various devices, including Windows, Mac, Chrome, and Linux laptops (side buttons are not compatible with macOS). Additionally, this bluetooth mouse for laptops automatically enters deep sleep mode after approximately 10-30 minutes of inactivity to conserve power; you can awake it by pressing the right or left button. Note: We recommend using branded batteries to ensure the mouse's longevity. When the battery is low, the LED light will blink (Requires 2 AAA batteries, not included).
  • 【36 MONTHS WARRANTY】If you encounter any problems in using the product, please feel free to contact our professional customer service team, enjoying TECKNET 36 Months Warranty (Registered Only).

Top Picks Compared

Here are the other options we recommend. Each brings something different to the table, depending on what you’re looking for.

TECKNET Ergonomic Mouse, Wireless Bluetooth Vertical Mouse, 4800 DPI Optical Tracking, 6 Adjustable DPI, Quiet Clicks, 2.4GHz with USB A Receiver, 12 Months...

$26.99 $29.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 19, 2025 12:45 pm

Features

Part Number TK-MS007
Model TK-MS007
Warranty 3 years
Color Black
  • 【Seamless Switching Between Three Devices】The ergonomic mouse features Bluetooth (5.0/3.0) and 2.4GHz USB A modes for connectivity. When connected via Bluetooth, The vertical mouse can effectively reduces the usage of your USB-A port (Bluetooth mode can connect to two devices simultaneously), which is convenient for devices without USB ports. To switch to 2.4GHz mode, simply plug in the USB receiver for quick connection without the need for additional software installation. With just a press of a button, you can easily switch between these two modes, enhancing your work efficiency (Note: The 2.4GHz receiver is built into the bottom of the mouse).
  • 【Higher DPI & 6 Adjustable Levels】This vertical ergonomic mouse is equipped with a high-performance chip and features 6 adjustable DPI levels (4800/3200/2400/1600/1200/800) to meet your daily needs. wireless mouse upgraded technology allows this ergonomic mouse to operate smoothly on different types of surfaces. When changing the DPI, the light will flash, with the number of flashes corresponding to the DPI level.
  • 【Silent Mouse】This computer mouse operates quietly, allowing for usage even in quiet environments like libraries. Additionally, the vertical mouse provides nearly silent clicks, helping avoid disturbances to others and ensuring your work or study remains undisturbed (Note: Only the left and right click buttons of the mouse are silent; other function buttons are not silent).
  • 【Ergonomic Design】The wireless mouse's ergonomic design offers ultimate comfort by placing your palm at a near-vertical angle on the desktop, reducing pressure and pain on your wrist caused by prolonged inverted mouse usage (Note: Mouse is designed for right-handed use only).
  • 【Broad Compatibility and Low Battery Warning】The wireless computer mouse is compatible with various devices, including Windows, Mac, Chrome, and Linux laptops (side buttons are not compatible with macOS). Additionally, this bluetooth mouse for laptops automatically enters deep sleep mode after approximately 10-30 minutes of inactivity to conserve power; you can awake it by pressing the right or left button. Note: We recommend using branded batteries to ensure the mouse's longevity. When the battery is low, the LED light will blink (Requires 2 AAA batteries, not included).
  • 【36 MONTHS WARRANTY】If you encounter any problems in using the product, please feel free to contact our professional customer service team, enjoying TECKNET 36 Months Warranty (Registered Only).

memzuoix Wired Mouse, USB Computer Mouse 1400 DPI Mobile Optical Mouse Ergonomic Design Computer Mice with 5FT Cord for Laptop, PC, Desktop, MacBook, 5...

$9.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 19, 2025 12:45 pm

Features

Model e67c1113-396d-4b25-9aec-9a77c0915818
Warranty 1 Year
Color Black
  • Plug & Play Super Easy To Use: memzuoix wired computer mouse offers a seamless installation process—just plug it into your computer’s USB port and it’s ready to use instantly. No need for additional drivers or software, making setup fast and effortless.Portable design make it easy to store in bag. It's the best mouse for a gifts.
  • Ergonomic Design for Comfort: Designed with your comfort in mind, this mouse features an ergonomic shape with a convex arc that closely follows the natural curve of your hand. This design evenly distributes pressure across your palm, reducing strain and fatigue during prolonged use.The sturdy scroll wheel with rubber makes sure that your hand will not slip when scrolling.
  • Stable and Reliable Connection: The 5FT USB cable provides a stable, uninterrupted connection, ensuring no latency and consistent performance. The cable is long enough to accommodate various computer setups, giving you freedom and flexibility in your workspace.
  • Reliable and Responsive Performance: This mouse features a 1,200 DPI optical sensor that provides consistent, reliable tracking on most surfaces. With four buttons—including left and right-click buttons, as well as side buttons for easy page navigation—and a scroll wheel, it offers all the essential functions needed for smooth and efficient operation.
  • Wide Compatibility: Compatible with a broad range of devices, including PCs, laptops, and notebooks, this mouse works seamlessly with Windows 11, 10, 8.1, 8, 7, Vista, and XP, ensuring it fits perfectly into any work or home environment.
  • memzuoix Customer Support: Enjoy peace of mind with our lifetime customer support and a 12-month warranty. the side buttons are not available for Mac OS, but the other function can be used normally. Our professional support team is always ready to assist with any questions or issues you may encounter.

DeLUX Wired Vertical Ergonomic Mouse, with 6 Programmable Buttons, 4200DPI, Removable Palm Rest, Reduces Wrist Pain and Carpal Tunnel for Medium Hands...

$19.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 19, 2025 12:45 pm

Features

Model M618XU
Warranty 1 year manufacturer
Color White&lightgray
Size Large/Medium
  • Ergonomic Volute Design: Unique vertical mouse design that prioritizes comfort and alleviates arm discomfort and stiffness, making it ideal for long hours of use
  • Entry-Level Ergonomics: Refined curve backside, thumb groove, and delicate button layout for a comfortable grip. Anti-skid rubber coating facilitates an easier transition to using a vertical mouse
  • Customizable DPI: Easily switch between 800, 1200, 2400, and 3200 DPI with the switch located at the top of the mouse. Adjust up to 4200 DPI via the driver software and enjoy a responsive 1000 polling rate for enhanced precision and faster response times
  • Removable Wrist Rest & Silent Button: The removable wrist rest lifts your forearm and mouse as a unified unit, preventing wrist friction and improving wrist protection. Experience comfortable mouse usage with this added feature. The mouse's silent button reduces noise during clicking, making it ideal for quiet environments like offices or libraries
  • Wide Compatibility: Compatible with Windows 8/10/11/XP/Mac OS operating systems (The side buttons and driver are not available for Mac). Please note that it may take a few days to adjust to the unique vertical design

TECKNET Ergonomic Mouse, Rechargeable Wireless Bluetooth Mouse (BT 5.0/5.0+2.4G), Vertical Mouse with Volume Knob, Quiet Clicks, Cordless Mice 6 Adjustable...

$18.99 $29.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 19, 2025 12:45 pm

Features

Part Number TK-MS042
Model TK-MS042
Warranty 3 years
Color Black
  • One-Click Multi-Device Control: This Bluetooth mouse enables seamless switching across 3 devices with advanced 2.4G + Dual Bluetooth 5.0 connectivity. Easily toggle between your computer (via USB-A receiver), smartphone, and tablet with just one click—no need for repeated pairing. Perfect for multitaskers who work, browse, and stream without interruption.
  • Media Control at Your Fingertips: Featuring a dedicated media control knob, you can instantly adjust volume and play/pause directly—all without lifting your fingers off the TECKNET optical wireless mouse. Enjoy seamless control that keeps you in the flow, whether you're working or relaxing.
  • Ergonomic Comfort: Say goodbye to wrist strain and hello to pain-free productivity! This ergonomic vertical mouse features a 57° tilt design and integrated palm support, this ergonomic mouse keeps your hand in a natural, relaxed position, helping prevent wrist fatigue and carpal tunnel syndrome—perfect for long hours of work.
  • Fast Charging & Long Battery Life: Enjoy up to 60 days of use on just 2.5 hours of charging with our long-lasting rechargeable wireless mouse. The 500mAh battery and Type-C fast charging (cable included) eliminate the hassle of battery swaps or interruptions.
  • Silent Click: Engineered with ultra-quiet button mechanisms, this silent USB computer mouse offers soft, tactile clicks without distracting noise. Perfect for libraries, late-night work, important meetings, and shared spaces—stay focused and productive without disturbing others in any environment.
  • 36-Month Warranty: If you experience any issues while using the product, our dedicated customer service team is here to assist you promptly and professionally. Enjoy peace of mind with the TECKNET 36-Month Warranty (Registered Customer Only).

TECKNET Ergonomic Mouse, 4800 DPI Wireless Vertical Mouse, 5 Adjustable DPI Levels, 6 Buttons, 2.4G Silent Wireless Mouse for Laptop, PC, Chromebook - Pink

$19.88
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 19, 2025 12:45 pm

Features

Model TK-MS017
Warranty 36 Months
Color Pink
  • 【Ergonomic Design】Ergonomic mouse with Ergonomic Design, 52°angle to the tabletop. A natural handshake position effectively relieves pressure on the wrist and arm, preventing RSI syndrome caused by long-term mouse use. It is the ideal choice for prolonged office work.
  • 【Comfortable Shape for Small/Medium Hands】The shape is rounded and comfortable with no sharp corners. Unlike other mice, this mouse is more suitable for small/medium hands, bringing a comfortable using experience and slowing down wrist fatigue. Product size: 4.13in*2.55in.
  • 【4800 High DPI】5 adjustable DPI settings: 4800/3200/2400/1600/800, catering to different usage habits. Even if you're new to it, you can easily master the mouse. TECKNET ergonomic wireless mouse optical tracking provides the smoothest and most precise cursor control on most surfaces.
  • 【Quick Click Buttons】The vertical mouse wireless added forward/back buttons provide convenience for web browsing. (Side buttons not supported on MAC OS).The features a silent click design, reducing click noise by over 99%, while ensuring optimal performance. This means you can feel every click but hardly hear any sound (note: forward/back buttons are not silent).
  • 【Stable Wireless Connection】The ergonomic mouse wireless uses 2.4GHz wireless technology, providing a stable and accurate connection without the need for any drivers. Simply plug the USB receiver into your laptop to start using the mouse, with a connection range of up to 32ft.
  • 【Wide Compatibility】The mouse ergonomic is compatible with a wide range of devices and can be used on desktops, laptops, PCs, MacBooks and other devices. Works with Windows 11/10/8/7/XP and Mac OS X10.4. It has a silent feature that allows it to be used in libraries, homes, offices, and other situations where low sound levels are required.

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