The 5 Best Ergonomic Mice for Windows

Choosing a in 2025 isn’t simple.

Some models looked good on paper, but only a few delivered in real use.

One came out ahead.

1
Lenovo WL310 Bluetooth Silent Mouse, Ergonomic, Adjustable DPI, Silent Clicks, Bluetooth 5.0, Portable for Windows, Mac, and Chromebook, Grey
Lenovo WL310 Bluetooth Silent Mouse, Ergonomic, Adjustable DPI, Silent Clicks, Bluetooth 5.0, Portable for Windows, Mac, and Chromebook, Grey
9.8
Amazon.com
2
Ergonomic Mouse, LEKVEY Vertical Wireless Mouse - Rechargeable 2.4G Optical Vertical Mice : 3 Adjustable DPI 800/1200/1600 Levels 6 Buttons, for Laptop, Mac, PC, Computer, Desktop, Notebook etc, Black
Ergonomic Mouse, LEKVEY Vertical Wireless Mouse - Rechargeable 2.4G Optical Vertical Mice : 3 Adjustable DPI 800/1200/1600 Levels 6 Buttons, for Laptop, Mac,...
9.8
Amazon.com
3
Anker 2.4G Wireless Vertical Ergonomic Optical Mouse for Work, Multi-Device Connectivity, 800/1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, MacBook - Black
Anker 2.4G Wireless Vertical Ergonomic Optical Mouse for Work, Multi-Device Connectivity, 800/1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, MacBook - Black
9.8
Amazon.com
4
SABLUTE Wireless Trackball Mouse, Ergonomic Bluetooth Rechargeable Computer Mouse, Backlit Rollerball Thumb Laptop mice with 5 Level DPI, Adjustable Angle, 3 Devices Connection for PC, Mac, Windows
SABLUTE Wireless Trackball Mouse, Ergonomic Bluetooth Rechargeable Computer Mouse, Backlit Rollerball Thumb Laptop mice with 5 Level DPI, Adjustable Angle, 3...
9.2
Amazon.com
5
Anker Ergonomic Optical USB Wired Vertical Mouse 1000/1600 DPI, 5 Buttons CE100
Anker Ergonomic Optical USB Wired Vertical Mouse 1000/1600 DPI, 5 Buttons CE100
8.3
Amazon.com

Top Pick

This is the product that stood out most — for performance, price, and overall value.

Anker 2.4G Wireless Vertical Ergonomic Optical Mouse for Work, Multi-Device Connectivity, 800/1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, MacBook - Black

$29.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 18, 2025 11:45 am

Features

Part Number AK-98ANWVM-UBA
Model AK-98ANWVM-UBA
Color Black
Is Adult Product
  • Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain.
  • 800 / 1200 / 1600 DPI Resolution Optical Tracking Technology provides more sensitivity than standard optical mice for smooth and precise tracking on a wide range of surfaces.
  • Added next/previous buttons provide convenience when webpage browsing; the superior choice for internet surfers, gamers and people who work at length at the computer.
  • Enters power saving mode (power is cut off completely) after 8 minutes idle, press right or left button for it to wake. Product dimensions: 120*62.8*74.8 mm; product weight: 3.4 oz.
  • Package includes: 1 Anker Wireless Vertical Ergonomic Optical Mouse (2 AAA batteries not included), 1 2.4G USB receiver (in the bottom of the mouse), 1 instruction manual. 18-month hassle-free warranty.

Top Picks Compared

Here are the other options we recommend. Each brings something different to the table, depending on what you’re looking for.

Anker 2.4G Wireless Vertical Ergonomic Optical Mouse for Work, Multi-Device Connectivity, 800/1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, MacBook - Black

$29.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 18, 2025 11:45 am

Features

Part Number AK-98ANWVM-UBA
Model AK-98ANWVM-UBA
Color Black
Is Adult Product
  • Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain.
  • 800 / 1200 / 1600 DPI Resolution Optical Tracking Technology provides more sensitivity than standard optical mice for smooth and precise tracking on a wide range of surfaces.
  • Added next/previous buttons provide convenience when webpage browsing; the superior choice for internet surfers, gamers and people who work at length at the computer.
  • Enters power saving mode (power is cut off completely) after 8 minutes idle, press right or left button for it to wake. Product dimensions: 120*62.8*74.8 mm; product weight: 3.4 oz.
  • Package includes: 1 Anker Wireless Vertical Ergonomic Optical Mouse (2 AAA batteries not included), 1 2.4G USB receiver (in the bottom of the mouse), 1 instruction manual. 18-month hassle-free warranty.

Ergonomic Mouse, LEKVEY Vertical Wireless Mouse - Rechargeable 2.4G Optical Vertical Mice : 3 Adjustable DPI 800/1200/1600 Levels 6 Buttons, for Laptop, Mac,...

$24.99 $39.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 18, 2025 11:45 am

Features

Part Number 7L-01
Model 7L-01
Warranty 1
Color Black
Release Date 2018-08-01T00:00:01Z
  • Ergonomic, Sleek and Rechargeable Design: Scientific ergonomic design encourages healthy neutral " handshake " wrist and arm positions for smoother movement and less overall strain. ** Most customers find it significantly reduces wrist pain and becomes very comfortable after just a 3-5 day adjustment
  • Multifunction and Convenient: Advanced " Page Back " and " Page Forward " functionality buttons provide convenience when web page browsing. 3 DPI levels ( 800 /1200/1600 ) -- Easily adjusts the sensitivity of the mouse
  • High-Capacity Rechargeable Battery: Built-in rechargeable battery. You no longer need to buy batteries, enjoy over 150 hours of continuous use on a single charge, very convenient !! Easy To Use -- One nano USB receiver at the bottom of the mouse, Just Plug and Play! No Bluetooth pairing or drivers needed
  • Widely Compatible: Widely compatible with Windows 2000 / XP / Vista / 7 / 8 / 10 / Linux. This Lekvey ergonomic mouse is also compatible with Mac OS. Once you get used to the vertical mouse, you'll love it so much and never want to go back to a regular one!
  • Lekvey Wireless Ergonomic Mouse: Revolutionize your work experience! Are you tired of using traditional mice that strain your wrist? Say goodbye to discomfort and hello to the Lekvey wireless carpal tunnel mouse! Designed with your ergonomic needs in mind, this innovative vertical ergonomic mouse offers a whole different level of comfort and efficiency
  • Package Includes: 1× Lekvey Rechargeable Wireless Vertical Ergonomic Mouse ( Size: 5.0" x 3.0" x 2.5"; recommended for medium or large hands), 1× 2.4G USB Receiver (in the bottom of the mouse), 1× 150cm Type-C Charging Cable, 1× User Manual. Backed by an industry-leading 36-month manufacturer's warranty

Lenovo WL310 Bluetooth Silent Mouse, Ergonomic, Adjustable DPI, Silent Clicks, Bluetooth 5.0, Portable for Windows, Mac, and Chromebook, Grey

$17.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 18, 2025 11:45 am

Features

Part Number GY51Q65621
Model GY51Q65621
Warranty 1 Year Manufacturer
Color grey
Release Date 2024-11-01T00:00:01Z
  • Ergonomic Wireless Mouse: The Lenovo WL310 Bluetooth Silent Mouse fits perfectly in your hand, reducing wrist strain and offering comfort for extended use on laptops or desktops
  • Silent Clicks for Any Space: Enjoy noiseless clicks with this wireless mouse, ideal for quiet workspaces, late-night projects, or shared environments
  • Customizable DPI Settings: Switch between 1000, 1200, and 1600 DPI for precision control, perfect for gaming, designing, or everyday computer tasks
  • Bluetooth 5.0 Connectivity: Stable, lag-free wireless performance for Windows PCs, MacBooks, Chromebooks, and Lenovo laptops. No USB receiver required
  • Portable & Stylish Design: Compact and lightweight, this grey mouse is easy to carry in your laptop bag, making it a great travel companion for professionals and students

SABLUTE Wireless Trackball Mouse, Ergonomic Bluetooth Rechargeable Computer Mouse, Backlit Rollerball Thumb Laptop mice with 5 Level DPI, Adjustable Angle, 3...

$36.99 $49.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 18, 2025 11:45 am

Features

Warranty 1 Year warranty
Color Black
  • Ergonomic design: You can choose the trackball mouse angle that suits you according to your needs, 0° and 18°. Proven: The 18° design is more in line with the natural drooping wrist angle of sitting posture, especially for people who use computer mouse for a long time, giving you a more comfortable experience and Reduces Muscle Strain
  • Precise thumb mouse: SABLUTE trackball mouse no longer needs to move the arm to control the cursor, but by turning the trackball, which will effectively reduce the fatigue and burden of the wrist and arm, and will not affect your efficiency even in a small space
  • Multi-device wireless connection: Plug and play. This wireless mouse can connect to three devices at the same time via Bluetooth and USB, and can switch freely between PC, laptop and iPad with just one click - no delay, thereby improving work efficiency. Compatible with Windows, Android, Mac OS PC laptops, desktops and other devices
  • Rechargeable and backlight: The Bluetooth mouse has a built-in rechargeable battery with long battery life, allowing you to say goodbye to dry batteries. This ergonomic mouse also has a tail atmosphere light, which you can choose to turn on or off, and there are multiple breathing light modes for you to choose
  • Adjustable DPI, silent click: 5 DPI levels (800/1200/1600/2400/4800) allow you to choose the cursor sensitivity that you need, making tracking smoother and more precise. Our computer mouse reduces 90% noise, so you don't worry about disturbing others when you focus on work
  • Mouse Recommended for Students: The UV-coated mouse surface is delicate and skin-friendly, making your experience more comfortable. It is also suitable as a gift for your children or friends during the back-to-school season. It can be easily used in study or work, doubling the efficiency
  • Warm Tips: If you are using a trackball mouse for the first time, it may take some time to get used to its operation. We recommend that you spend 1-2 weeks to adapt, as many users find that this helps reduce the pressure and pain on the wrist caused by long-term use of the mouse and improves comfort

Anker Ergonomic Optical USB Wired Vertical Mouse 1000/1600 DPI, 5 Buttons CE100

$25.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 18, 2025 11:45 am

Features

Part Number AK-98ANWVM-BA-0013
Model AK-98ANWVM-BA
Color Black
  • Ultimate Comfort: Embrace the comfort of Anker's Ergonomic Mouse, scientifically designed to encourage healthy neutral "handshake" wrist and arm positions. This wired mouse ensures smoother movement and significantly less strain, making it an ideal choice for extended computer use.
  • Enhanced Sensitivity: Experience precision like never before with our 1000/1600 DPI Resolution Optical Tracking Technology. This wired ergonomic mouse offers superior sensitivity compared to standard optical mice, ensuring smooth and precise tracking on a variety of surfaces to boost your productivity and computing experience.
  • Effortless Navigation: Navigate webpages with ease using the added next/previous buttons. This ergonomic wired mouse is not only ideal for internet surfers but also for gamers and professionals who spend long hours on the computer.
  • Compact and Lightweight: The Anker Vertical Ergonomic Optical Mouse, with its 1.5m/4.9ft USB cable and dimensions of 120*62.8*74.8 mm, offers a lightweight design of just 5.3 oz, ensuring a comfortable and convenient user experience.
  • Customer Value: Our package includes 1 Anker Vertical Ergonomic Optical Wired Mouse (with 4.9 ft cable), and a detailed instruction manual. We are committed to our customers and offer an 18-month warranty along with a lifetime technical support guarantee.

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Digital Wellness Labs
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