The 5 Best Ambidextrous Ergonomic Mice
Choosing a in 2025 isn’t simple.
We compared dozens of products to figure out which ones are worth your attention.
The best option wasn’t the most expensive — but it delivered where it counts.
1
Anker 2.4G Wireless Vertical Ergonomic Optical Mouse for Work, Multi-Device Connectivity, 800/1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, MacBook - Black
9.7
Amazon.com
2
Kensington Orbit Trackball Mouse with Scroll Ring (K72337US), 4 1/2X5 1/2X2"
9.1
Amazon.com
3
Anker Ergonomic Optical USB Wired Vertical Mouse 1000/1600 DPI, 5 Buttons CE100
8.6
Amazon.com
4
POJTK Ergonomic Wireless Rechargeable Mouse, Bluetooth+USB A+Type C(3 in 1) Connection, 5 Levels Up to 4800 DPI, 6 Silent Buttons, 2.4GHz Carpal Tunnel...
8.4
Amazon.com
5
TECKNET Ergonomic Mouse Wireless, Rechargeable Mouse Wireless Silent for Carpal Tunnel Right Hand, 2.4GHz USB Vertical Mouse Wireless for Laptop, 5...
8.3
Amazon.com
Top Pick
This is the product that stood out most — for performance, price, and overall value.
Anker 2.4G Wireless Vertical Ergonomic Optical Mouse for Work, Multi-Device Connectivity, 800/1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, MacBook - Black
$29.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | AK-98ANWVM-UBA |
| Model | AK-98ANWVM-UBA |
| Color | Black |
| Is Adult Product |
- Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain.
- 800 / 1200 / 1600 DPI Resolution Optical Tracking Technology provides more sensitivity than standard optical mice for smooth and precise tracking on a wide range of surfaces.
- Added next/previous buttons provide convenience when webpage browsing; the superior choice for internet surfers, gamers and people who work at length at the computer.
- Enters power saving mode (power is cut off completely) after 8 minutes idle, press right or left button for it to wake. Product dimensions: 120*62.8*74.8 mm; product weight: 3.4 oz.
- Package includes: 1 Anker Wireless Vertical Ergonomic Optical Mouse (2 AAA batteries not included), 1 2.4G USB receiver (in the bottom of the mouse), 1 instruction manual. 18-month hassle-free warranty.
Top Picks Compared
Here are the other options we recommend. Each brings something different to the table, depending on what you’re looking for.
Anker 2.4G Wireless Vertical Ergonomic Optical Mouse for Work, Multi-Device Connectivity, 800/1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, MacBook - Black
$29.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | AK-98ANWVM-UBA |
| Model | AK-98ANWVM-UBA |
| Color | Black |
| Is Adult Product |
- Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain.
- 800 / 1200 / 1600 DPI Resolution Optical Tracking Technology provides more sensitivity than standard optical mice for smooth and precise tracking on a wide range of surfaces.
- Added next/previous buttons provide convenience when webpage browsing; the superior choice for internet surfers, gamers and people who work at length at the computer.
- Enters power saving mode (power is cut off completely) after 8 minutes idle, press right or left button for it to wake. Product dimensions: 120*62.8*74.8 mm; product weight: 3.4 oz.
- Package includes: 1 Anker Wireless Vertical Ergonomic Optical Mouse (2 AAA batteries not included), 1 2.4G USB receiver (in the bottom of the mouse), 1 instruction manual. 18-month hassle-free warranty.
Kensington Orbit Trackball Mouse with Scroll Ring (K72337US), 4 1/2X5 1/2X2"
$39.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | K72337US |
| Model | K72337US |
| Warranty | 5 Year Warranty |
| Color | Black-Blue |
| Is Adult Product | |
| Release Date | 2009-10-07T00:00:01Z |
| Size | 4 1/2X5 1/2X2" |
| Language | English |
- Optical tracking technology provides precise cursor movement for superior accuracy so you can get where you want on the screen Quickly with less hand movement, improving productivity and efficiency; The blue 40mm ball has been specially designed with an absolute spherical, hard surface for precise tracking and control
- Unique scroll Ring let you move up and down web pages or documents with ease; ambidextrous design works equally well for both right-handed and left-handed users
- Detachable Wrist rest softly cushions and cradles the hand and wrist in an ergonomic position for pain-free productivity during extended periods of activity on the computer
- Free downloadable KensingtonKonnect software provides a personalized experience, giving you the ability to assign a wide variety of program functions to each of the 2 buttons, as well as adjusting cursor and scrolling speeds
- ChromeOS user can get HID functions for a trackball but will not be able to customize their device through KensingtonWorks.
Anker Ergonomic Optical USB Wired Vertical Mouse 1000/1600 DPI, 5 Buttons CE100
$25.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | AK-98ANWVM-BA-0013 |
| Model | AK-98ANWVM-BA |
| Color | Black |
- Ultimate Comfort: Embrace the comfort of Anker's Ergonomic Mouse, scientifically designed to encourage healthy neutral "handshake" wrist and arm positions. This wired mouse ensures smoother movement and significantly less strain, making it an ideal choice for extended computer use.
- Enhanced Sensitivity: Experience precision like never before with our 1000/1600 DPI Resolution Optical Tracking Technology. This wired ergonomic mouse offers superior sensitivity compared to standard optical mice, ensuring smooth and precise tracking on a variety of surfaces to boost your productivity and computing experience.
- Effortless Navigation: Navigate webpages with ease using the added next/previous buttons. This ergonomic wired mouse is not only ideal for internet surfers but also for gamers and professionals who spend long hours on the computer.
- Compact and Lightweight: The Anker Vertical Ergonomic Optical Mouse, with its 1.5m/4.9ft USB cable and dimensions of 120*62.8*74.8 mm, offers a lightweight design of just 5.3 oz, ensuring a comfortable and convenient user experience.
- Customer Value: Our package includes 1 Anker Vertical Ergonomic Optical Wired Mouse (with 4.9 ft cable), and a detailed instruction manual. We are committed to our customers and offer an 18-month warranty along with a lifetime technical support guarantee.
POJTK Ergonomic Wireless Rechargeable Mouse, Bluetooth+USB A+Type C(3 in 1) Connection, 5 Levels Up to 4800 DPI, 6 Silent Buttons, 2.4GHz Carpal Tunnel...
$19.99
PRIMEPRIME
in stock
Amazon.com
Features
| Warranty | 1 Year Manufacturer |
| Color | Black |
- 【Vertical ergonomic design】POJTK ergonomic mouse adopts a scientific vertical design, with an angle of 58 degrees to the desktop. It fits the curvature of the palm very well, encourages a healthy and neutral "handshake" posture, and provides ultimate comfort. Promote smoother movement, reduce stress on the wrist and arm, and relieve wrist muscle fatigue and pain.
- 【Multiple connection methods】This vertical ergonomic mouse uses three connection methods: Bluetooth 5.3+2.4GHz USB A+USB C, which can switch seamlessly between two devices without repeatedly plugging and unplugging the USB receiver. When connecting devices via Bluetooth, you can save a USB A or Type C port. It is very suitable for devices without USB ports. When using the 2.4GHz USB connection mode, you only need to plug in the USB receiver to quickly connect. It is equipped with both USB A and USB C receivers. When there is only a Type C interface on the device, plug the USB C receiver into the USB A receiver, and then plug it into the Type C interface of the device to use it.
- 【5-level adjustable high DPI】The vertical mouse with advanced optical tracking technology has 5 levels of adjustable DPI, up to 4800DPI (800/1600/2400/3200/4800). High numerical DPI provides higher sensitivity than ordinary optical mice, ensuring that the mouse can achieve accurate tracking on various surfaces.
- 【Rechargeable Mouse】The wireless vertical mouse is rechargeable and does not require additional batteries, saving the cost of purchasing batteries. After a full charge, it can be used for 1-3 months, depending on usage habits and daily usage time. If it is idle for ten minutes, the mouse will enter standby mode to extend the battery life. You only need to click any button once to wake up the mouse. (When using the mouse for the first time, please fully charge it before.)
- 【Silent Mouse】The carpal tunnel mouse has 6 buttons and adopts a silent design, and there is almost no sound when clicking. It is very suitable for use in quiet environments such as offices, homes, conference rooms, libraries, etc., effectively avoiding disturbing colleagues, family or strangers. The front and back shortcut keys can quickly and conveniently enter or exit web pages, improving browsing efficiency. (Note: The front and back shortcut keys cannot be used in macOS)
- 【Wide Compatibility】 This ergonomic computer mouse is compatible with a variety of systems, including Windows, Linux, macOS, Unix and other systems. Compatible with most devices on the market, including laptops, desktops, PCs, Macbooks, Chormebooks, tablets and other devices. It is also suitable for devices equipped with USB A or Type C ports. Eliminate the worry of incompatibility with your device.
TECKNET Ergonomic Mouse Wireless, Rechargeable Mouse Wireless Silent for Carpal Tunnel Right Hand, 2.4GHz USB Vertical Mouse Wireless for Laptop, 5...
$24.99
PRIMEPRIME
in stock
Amazon.com
Features
| Model | TK-MS007 |
| Warranty | 36 Months |
| Color | Black |
- Ergonomic Design: This ergonomic mouse promotes a natural wrist and arm position, minimizing hand fatigue from prolonged use. With a vertical layout, the vertical mouse aids in maintaining a comfortable posture, reducing shoulder and neck strain.
- Long-Lasting & Rapid Charging: Equipped with a 600mAh battery, the ergonomic mouse wireless fully charges in 1.5 hours via Type-C (cable included). The vertical mouse delivers a 2-month runtime per charge(depending on the actual frequency of use).
- Stable Wireless Vertical Mouse: 2.4 GHz technology ensures reliable 10m connectivity with zero interference. Plug-and-play via nano USB receiver (no drivers required). Ergonomic design maintains seamless productivity for office/remote professionals.
- Silent Ergonomic Mouse Wireless: Silent-click tech eliminates noise in shared spaces (libraries/offices/homes). The vertical mouse is perfect for mobile workers in noise-sensitive environments, blending ergonomic comfort with wireless convenience. Note: The left and right click keys of this silent mouse are silent, and the other auxiliary keys are not silent.
- Adjustable DPI Vertical Mouse: 5-step 4800-800 DPI adapts to tasks/habits. Tru-Wave optical tracking surpasses traditional mice with enhanced sensitivity, ensuring precision on multiple surfaces (excluding glass). Professional-grade responsiveness for graphic design/office workflows.
- Wide Compatibility: 2.4GHz ergonomic mouse wireless ensures stable connectivity with USB-A devices (desktops/laptops/PCs). The vertical mouse seamlessly fits most computer models featuring USB-A port interfaces but excludes USB-C.
- Power Saving Mode: The ergonomic mouse wireless Features an automatic sleep mode that automatically turns off and saves power after 8 minutes of inactivity—click any button to reactivate the vertical mouse.
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