Best Ergonomic Mice with Programmable Buttons
Choosing a in 2025 isn’t simple.
We looked at reviews, specs, and overall performance to narrow it down.
One stood out across the board.
1
Redragon M908 Impact RGB LED MMO Gaming Mouse with 12 Side Buttons, Optical Wired Ergonomic Mouse with Max 12,400DPI, High Precision, 18 Programmable Macro...
9.5
Amazon.com
2
Ergodriven Om Handshake Vertical Mouse | Wireless Ergonomic Mouse | Rechargeable | Silent Click Micro-Force Switches | OLED Screen | Reduces Tension and...
9.5
Amazon.com
3
Redragon M811 Aatrox MMO Gaming Mouse, 15 Programmable Buttons Wired RGB Mouse w/Ergonomic Natural Grip Build, 10 Side Macro Keys, Software Supports DIY...
9.5
Amazon.com
4
TRELC Gaming Mouse with 5 D Rocker, Ergonomic Mouse with 10000 DPI/11 Programmable Buttons, Vertical Gaming Mice Wired for PC/Laptop/E-Sports/Gamer (Black)
9
Amazon.com
5
Logitech MX Ergo S Advanced Wireless Trackball Mouse, USB-C Rechargeable Wireless Ergonomic Mouse with Bluetooth and Encrypted Dongle, 6 Programmable...
8
Amazon.com
Top Pick
This is the product that stood out most — for performance, price, and overall value.
Redragon M811 Aatrox MMO Gaming Mouse, 15 Programmable Buttons Wired RGB Mouse w/Ergonomic Natural Grip Build, 10 Side Macro Keys, Software Supports DIY...
$37.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | 682983705 |
| Model | M811 |
| Warranty | 1 year |
| Color | Black |
| Size | M811 Wired |
- Pentakill, 5 DPI Levels - Geared with 5 redefinable DPI levels (default as: 500/1000/2000/3000/6200), easy to switch between different game needs. Dedicated demand of DPI options between 500-12400 is also available to be processed by software.
- Take The Advanced Shot - 15 programmable buttons are all editable with customizable tactical keybinds in whatever game or work you are engaging. Default 2 + 8 epic MMO side buttons will get you all covered, hit your hotkeys/keybinds faster than ever with M811.
- Comfort & Natural Grip - Following the natural structure of the human hand, the M811 is perfectly shaped for long-lasting use. It makes you easily to handle am to pm gaming parties or overtime & overdue work with less fatigue.
- 5 Decent Backlit Modes - Turn the backlit on and make some kills in your gaming battlefield. The hyped dynamic RGB backlit vibe will never let you down when decorating your gaming space, it would be better with other Redragon accessories with lights on.
- Uncompromised Driver Support - All 15 buttons with hotkeys, media, DPI settings and 16.8 million color lighting effects are all customizable with Redragon dedicated software. Pre-aim your opponents and get overwhelming to the victory in your exactly wanted way.
More Worth Considering
Here are the other options we recommend. Each brings something different to the table, depending on what you’re looking for.
Redragon M811 Aatrox MMO Gaming Mouse, 15 Programmable Buttons Wired RGB Mouse w/Ergonomic Natural Grip Build, 10 Side Macro Keys, Software Supports DIY...
$37.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | 682983705 |
| Model | M811 |
| Warranty | 1 year |
| Color | Black |
| Size | M811 Wired |
- Pentakill, 5 DPI Levels - Geared with 5 redefinable DPI levels (default as: 500/1000/2000/3000/6200), easy to switch between different game needs. Dedicated demand of DPI options between 500-12400 is also available to be processed by software.
- Take The Advanced Shot - 15 programmable buttons are all editable with customizable tactical keybinds in whatever game or work you are engaging. Default 2 + 8 epic MMO side buttons will get you all covered, hit your hotkeys/keybinds faster than ever with M811.
- Comfort & Natural Grip - Following the natural structure of the human hand, the M811 is perfectly shaped for long-lasting use. It makes you easily to handle am to pm gaming parties or overtime & overdue work with less fatigue.
- 5 Decent Backlit Modes - Turn the backlit on and make some kills in your gaming battlefield. The hyped dynamic RGB backlit vibe will never let you down when decorating your gaming space, it would be better with other Redragon accessories with lights on.
- Uncompromised Driver Support - All 15 buttons with hotkeys, media, DPI settings and 16.8 million color lighting effects are all customizable with Redragon dedicated software. Pre-aim your opponents and get overwhelming to the victory in your exactly wanted way.
Ergodriven Om Handshake Vertical Mouse | Wireless Ergonomic Mouse | Rechargeable | Silent Click Micro-Force Switches | OLED Screen | Reduces Tension and...
$29.00
PRIMEPRIME
in stock
Amazon.com
Features
| Model | 14001 |
| Warranty | 2 Year Manufacturer |
| Color | Black |
- PERFECT ERGONOMICS. You hold your mouse for hours every day, so it's critical to use a good one! A vertical mouse is a must, and Om has the most ergonomic shape on the market, plus silent, micro-force buttons to further reduce tension and fatigue.
- FEEL BETTER AT WORK AND AFTER. A vertical mouse, or handshake mouse, puts your wrist and shoulder into a healthy position, reducing stress and pain.
- PRECISE PERFORMANCE. Om has 4 DPI settings (1200,1600,2000,2400) to ensure you get the best sensitivity for your body and workspace. Om's onboard OLED screen makes finding your perfect setting simple. Now that's good ergonomics.
- HASSLE-FREE. Om has a rechargeable Li-ion battery with an ultra long life, and ships with at least 50% battery charge level, enough to last for weeks. So you don't need to plug it in, or find batteries and a screwdriver.
- CONNECT SEAMLESSLY. When we decided to make our vertical mouse wireless, we knew it had to be a perfect connection. Om is wireless with both 2.4GHz (dongle) and BLUETOOTH connectivity, compatible with both Mac and PC.
- MAXIMIZE PRODUCTIVITY with 5 easily customizable buttons and an onboard screen. In less than 10 seconds (and without downloading software), you can assign custom functions to your vertical mouse like one-click copy or paste.
- MOUSE WITH CONFIDENCE with a 2-year manufacturer's warranty from a proven ergonomics brand. You can rest easy knowing that your vertical mouse will be improving your ergonomics for a long time.
Redragon M908 Impact RGB LED MMO Gaming Mouse with 12 Side Buttons, Optical Wired Ergonomic Mouse with Max 12,400DPI, High Precision, 18 Programmable Macro...
$32.89
$46.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | 707062801 |
| Model | M908 |
| Warranty | 1 year |
| Color | Black |
| Size | Wired M908 |
- Professional Gaming Mouse - Redragon M908 optical gaming mouse is designed with up to 12400 DPI, 5 adjustable DPI levels (500/1000/2000/3000/6200 DPI) meet your multiple needs, either for daily work or gaming. DPI can be adjusted freely by ±100 from 200 to 12400 via software. 1000 Hz polling rate, 30G acceleration and high-precision Pixart PAW3327 Sensor giving you a greater edge over your competition.
- RGB Backlight & Programmable Buttons - 16.8 million RGB LED color options (LED Backlight can be disabled). 18 programmable buttons, 5 memory profiles each with a dedicated light color for quick identification. Comes with 8-piece weight tuning set (2.4g x8), easy to change the weight to suit your games.
- Comfort & Precision At Your Hands - Redragon M908 gaming mouse is an essential computer accessory for die-hard with its aggressive design for hands! You will be amazed by the unmatched comfort, lethal accuracy and killer precision of our durable, desktop and laptop pro gaming mouse!
- High-end Design - Redragon M908 Mouse features 6 buttons and 12 MMO programmable side buttons. Durable smooth TEFLON feet pads for ultimate gaming control. 6ft braided-fiber cable with gold-plated USB connector ensures greater durability.
- Die-hard Players Choice - Whether you are targeting, aiming, slashing or attacking, a professional gaming mouse is your basic weapon! The mouse will be your ideal partner. Compatible with Windows 2000/ME/XP/03/VISTA/7/8/10 system for programmable using and Mac OS for normal using.
TRELC Gaming Mouse with 5 D Rocker, Ergonomic Mouse with 10000 DPI/11 Programmable Buttons, Vertical Gaming Mice Wired for PC/Laptop/E-Sports/Gamer (Black)
$28.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | ff-maus |
| Model | ffa9f2bc-df4c-43d8-b09b-b9ba1c59d13a |
| Color | Black |
- 【Ergonomic Vertical Mouse】This vertical mouse bases on ergonomics, effectively reducing user’s wrist strain and muscle pain by a natural handshake griping way. An optimal healer for wrist pain, shoulder fatigue, Carpal Tunnel Syndrome and tendinitis.
- 【5 Direction Rocker】An integrated 5 orientations rocker helps gamer to achieve their best performance in each campaign. In this gaming mouse, 1 rocker equals 5 keys. Thumb control, the realization of "front, rear, left, right, down pressure" operation. Adapted to FPS, MOBA, MMO and other different types of games.
- 【Programmable Buttons】 Intelligent macro defines function allows users to customize all 11 buttons according to different individualities. Via attached software(please refer to manual), build a professional gaming mouse for you own. Programmable data will be saved in the mouse, if plug it into a new computer there is no reset hassle.
- 【High Configuration】5 level DPI varying velocity from 1500 to 10000 sensor. This gaming mouse also adapted PMW3325 photoelectric chip, with 100IPS movement speed, 20G Acceleration, 5000FPS scanning frequency for achieving your superior gameplay.
- 【Preset RGB Led Light】RGB color-changing lamp belt is set on both sides. Customize the RGB light by neon, Marquee or Streamer effects (total 5 lighting effects) to increase the game atmosphere.
Logitech MX Ergo S Advanced Wireless Trackball Mouse, USB-C Rechargeable Wireless Ergonomic Mouse with Bluetooth and Encrypted Dongle, 6 Programmable...
$119.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | 910-007259 |
| Model | 910-007259 |
| Warranty | 1 Year limited Hardware Warranty |
| Color | Graphite |
| Release Date | 2024-09-13T00:00:01Z |
| Size | One Size |
- Advanced thumb control: The MX Ergo S Advanced wireless trackball mouse gives more control with less movement; switch between speed and high-precision tracking at the tap of a button
- 20-degree tilt: A wireless ergonomic mouse with a tilt angle for better forearm posture, reducing muscle strain by 27% (1); now with 80% quieter clicks (5)
- Contoured for your hand: The MX Ergo S is certified by ergonomists for improved comfort, with a sculpted ergonomic design, 20-degree tilt angle, and soft rubber grip; for medium- to large-sized hands
- Boost your productivity using the Logi Options+ App (2): Experience enhanced control in your daily tasks with 6 customizable buttons, time-saving shortcuts, and Smart Actions
- Quick USB-C charging: Enjoy up to 24h of use from a 1 min charge or up to 120 days (3) with a full charge; charges with a USB Type C to Type C or USB Type A to Type C cable (not included)
- Dual wireless connectivity: Connect your rechargeable wireless mouse via Bluetooth or Logi Bolt USB receiver (included); supported by an Easy-Switch button
- Made with recycled plastic: The plastic parts in the MX Ergo S wireless rechargeable mouse are made of 20% certified post-consumer recycled plastic (4)
- Complete your advanced setup: Pair the MX Ergo S with the ERGO K860 ergonomic split-curved keyboard, featuring an integrated cushioned palm rest for all-day comfort
- Note: In case of Wireless mouse, the USB receiver will be provided inside or along with the mouse
This post contains affiliate links. Purchases may earn me a commission at no extra cost to you.
