Best Vertical Mice for Large Hands
Choosing a in 2025 isn’t simple.
We looked at reviews, specs, and overall performance to narrow it down.
The best option wasn’t the most expensive — but it delivered where it counts.
1
Logitech MX Vertical Wireless Mouse – Ergonomic Design Reduces Muscle Strain, Move Content Between 3 Windows and Apple Computers, Rechargeable, Graphite
9.9
Amazon.com
2
AUTLEY Ergonomic Mouse for Large Hands, Vertical Mouse, 2.4GHz Wireless Computer Mouse for Windows/macOS - 6 Buttons, Low Power Warning, 800/1200/1600 DPI,...
9.4
Amazon.com
3
Anker 2.4G Wireless Vertical Ergonomic Optical Mouse for Work, Multi-Device Connectivity, 800/1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, MacBook - Black
9.4
Amazon.com
4
Logitech Lift Vertical Ergonomic Mouse, Wireless Bluetooth or USB Receiver, Quiet Clicks, 4 Buttons, Left Hand Wireless Mouse, Windows/macOS/iPadOS, Laptop,...
9.2
Amazon.com
5
![J-Tech Digital Wired Ergonomic Vertical USB Mouse with Adjustable Sensitivity (600/1000/1600 DPI), Scroll Endurance, Removable Palm Rest & Thumb Buttons [V628]](https://m.media-amazon.com/images/I/41Rr0XulZRL._SS520_.jpg)
J-Tech Digital Wired Ergonomic Vertical USB Mouse with Adjustable Sensitivity (600/1000/1600 DPI), Scroll Endurance, Removable Palm Rest & Thumb Buttons [V628]
9
Amazon.com
Top Pick
This is the product that stood out most — for performance, price, and overall value.
Logitech MX Vertical Wireless Mouse – Ergonomic Design Reduces Muscle Strain, Move Content Between 3 Windows and Apple Computers, Rechargeable, Graphite
$99.90
$119.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | 910-005447 |
| Model | 910-005447 |
| Warranty | Manufacturer’s warranty can be requested from customer service. |
| Color | GRAPHITE |
| Release Date | 2018-08-20T00:00:01Z |
| Size | Mouse for Medium-Large Hands |
- Logitech MX Vertical Wireless Ergonomic Mouse is a great fit for medium to large size right hands
- NATURAL HANDSHAKE POSITION: MX Vertical’s natural handshake position reduces muscular activity by 10 percent compared to a standard mouse – without any loss in overall performance
- 57° VERTICAL ANGLE FOR IMPROVED WRIST POSTURE: MX Vertical’s unique 57° vertical angle reduces the pressure on your wrist, while your thumb is positioned comfortably on the thumb rest
- USER TESTED. ERGONOMIST-APPROVED: MX Vertical has been designed and tested with criteria set out by leading ergonomists – improve posture, lower muscle strain, and reduce wrist pressure
- ADVANCED OPTICAL TRACKING WITH CURSOR SPEED SWITCH: The 4000 DPI high-precision sensor results in 4x less hand movement and reduces fatigue. The cursor speed switch instantly adjusts DPI speed and accuracy with the touch of a button
- COMFORT FORM WITH TEXTURED SURFACE: MX Vertical is shaped for the human hand and smooth to the touch. Its unique form fits a variety of hand shapes and sizes, and the textured rubber surface assures a natural grip
- Uses FSC-certified paper for responsible packaging
More Worth Considering
Here are the other options we recommend. Each brings something different to the table, depending on what you’re looking for.
Logitech MX Vertical Wireless Mouse – Ergonomic Design Reduces Muscle Strain, Move Content Between 3 Windows and Apple Computers, Rechargeable, Graphite
$99.90
$119.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | 910-005447 |
| Model | 910-005447 |
| Warranty | Manufacturer’s warranty can be requested from customer service. |
| Color | GRAPHITE |
| Release Date | 2018-08-20T00:00:01Z |
| Size | Mouse for Medium-Large Hands |
- Logitech MX Vertical Wireless Ergonomic Mouse is a great fit for medium to large size right hands
- NATURAL HANDSHAKE POSITION: MX Vertical’s natural handshake position reduces muscular activity by 10 percent compared to a standard mouse – without any loss in overall performance
- 57° VERTICAL ANGLE FOR IMPROVED WRIST POSTURE: MX Vertical’s unique 57° vertical angle reduces the pressure on your wrist, while your thumb is positioned comfortably on the thumb rest
- USER TESTED. ERGONOMIST-APPROVED: MX Vertical has been designed and tested with criteria set out by leading ergonomists – improve posture, lower muscle strain, and reduce wrist pressure
- ADVANCED OPTICAL TRACKING WITH CURSOR SPEED SWITCH: The 4000 DPI high-precision sensor results in 4x less hand movement and reduces fatigue. The cursor speed switch instantly adjusts DPI speed and accuracy with the touch of a button
- COMFORT FORM WITH TEXTURED SURFACE: MX Vertical is shaped for the human hand and smooth to the touch. Its unique form fits a variety of hand shapes and sizes, and the textured rubber surface assures a natural grip
- Uses FSC-certified paper for responsible packaging
Anker 2.4G Wireless Vertical Ergonomic Optical Mouse for Work, Multi-Device Connectivity, 800/1200 /1600 DPI, 5 Buttons for Laptop, Desktop, PC, MacBook - Black
$29.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | AK-98ANWVM-UBA |
| Model | AK-98ANWVM-UBA |
| Color | Black |
| Is Adult Product |
- Scientific ergonomic design encourages healthy neutral "handshake" wrist and arm positions for smoother movement and less overall strain.
- 800 / 1200 / 1600 DPI Resolution Optical Tracking Technology provides more sensitivity than standard optical mice for smooth and precise tracking on a wide range of surfaces.
- Added next/previous buttons provide convenience when webpage browsing; the superior choice for internet surfers, gamers and people who work at length at the computer.
- Enters power saving mode (power is cut off completely) after 8 minutes idle, press right or left button for it to wake. Product dimensions: 120*62.8*74.8 mm; product weight: 3.4 oz.
- Package includes: 1 Anker Wireless Vertical Ergonomic Optical Mouse (2 AAA batteries not included), 1 2.4G USB receiver (in the bottom of the mouse), 1 instruction manual. 18-month hassle-free warranty.
AUTLEY Ergonomic Mouse for Large Hands, Vertical Mouse, 2.4GHz Wireless Computer Mouse for Windows/macOS - 6 Buttons, Low Power Warning, 800/1200/1600 DPI,...
$19.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | AEM04A |
| Model | AEM04A |
| Warranty | 1 Year Warranty |
| Size | Large |
- 【Innovative Ergonomic Design】With the arch contour, the ergonomic mouse fits your hand comfortably. Alleviates wrist discomfort or fatigue by allowing your wrist to rest more naturally. Pinky rest for enhancing overall comfort.
- 【Large Size & Right-Handed】This vertical mouse is designed for medium to large hands. Very easy and natural to hold. Good for home/office use. For beginners, it may take a few days to get used to. (NOTE: not for small hands)
- 【Low Power Warning】If ergo mouse is about to run out of power, the side indicator light will flash red to avoid the sudden disconnection. Powered by 1*AA battery(not included), lasts about 3-4 weeks.
- 【Wireless & Plug and Play】Wireless 2.4G connection, no more tangled cords cluttering your desk. Plug and play, no drivers needed, works out of box. This ergonomic mouse wireless compatible with Windows, macOS, Linux.
- 【3 DPI Levels, Advanced Thumb Buttons】800/1200/1600 DPI suits different tasks or preferences. Just click forward or back button by the thumb. The large mouse allows you browse webpage or documents easily. (NOTE: Forward & back buttons not recognized on macOS)
- 【Warranty Service】You will enjoy 90-Day money back guarantee, 12-Month warranty(replacement service). We value customers' satisfaction and suggestions above all else. If you have any product issue, do not feel upset, please contact us for help. You will get reply within 24 hours.
Logitech Lift Vertical Ergonomic Mouse, Wireless Bluetooth or USB Receiver, Quiet Clicks, 4 Buttons, Left Hand Wireless Mouse, Windows/macOS/iPadOS, Laptop,...
$79.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | 910-006467 |
| Model | 910-006467 |
| Warranty | 1 Year Limited Hardware Warranty |
| Color | GRAPHITE |
| Release Date | 2022-04-19T00:00:01Z |
| Size | Mouse |
- Lift yourself up: When desk work gets you down, lift yourself up with this Logitech Wireless Ergonomic Mouse - a great fit for small to medium left hands
- Raise your hand into comfort with this computer mouse wireless: Rest on Lift upright mouse throughout the day with a softly textured grip and snug thumb rest for level-above coziness
- 57 degrees of soothe: This wireless ergonomic mouse promotes a more natural posture in the forearm for comfort and productivity, for day-long comfort and productivity
- Relax into focus: Settle into work with this ergonomic wireless mouse featuring easy-to-reach customizable buttons, whisper-quiet clicks, and a SmartWheel for smooth, seamless scrolling
- Ergo-certified: This wireless vertical mouse has been designed, developed, tested, and approved according to criteria set out by leading ergonomists
J-Tech Digital Wired Ergonomic Vertical USB Mouse with Adjustable Sensitivity (600/1000/1600 DPI), Scroll Endurance, Removable Palm Rest & Thumb Buttons [V628]
$22.99
$28.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | JTD-325 |
| Model | V628 |
| Warranty | 1 year |
| Color | Black |
| Is Adult Product | |
| Size | V628 Wired |
- Ergonomic Wireless Design: The J-Tech Digital V638’s comfortable, ergonomic “handshake” design greatly reduces arm/wrist/hand strain while providing relief for carpal tunnel syndrome. Back/forward thumb buttons provide extra convenience. (Button functionality can also be changed or reassigned using third-party software.) Works on most non-metallic surfaces. The built-in lithium battery is fully rechargeable.
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