Top 5 Best Ergonomic Mice with RGB Lighting
Choosing a in 2025 isn’t simple.
Some models looked good on paper, but only a few delivered in real use.
One stood out across the board.
1
TRELC Gaming Mouse with 5 D Rocker, Ergonomic Mouse with 10000 DPI/11 Programmable Buttons, Vertical Gaming Mice Wired for PC/Laptop/E-Sports/Gamer (Black)
9.9
Amazon.com
2
Nulea M504 Wired Vertical Mouse, USB Ergonomic Optical Mouse with 4 Adjustable DPI, 11 RGB Backlight Modes, Compatible for Laptop, PC, Desktop, Mac, Grey
9.4
Amazon.com
3
AooKoNi Wireless Gaming Mouse，Ergonomic Mouse with 5 Adjustable DPI up to 7200, RGB Breathing Lights, Compatible with Laptop, Chromebook, PC, Desktop, Mac,...
9.2
Amazon.com
4
Redragon M602 Griffin RGB Gaming Mouse, RGB Spectrum Backlit Ergonomic Mouse with 7 Programmable Backlight Modes up to 7200 DPI for Windows PC Gamers (Black,...
8.8
Amazon.com
5
mobiproduct Wireless Gaming Mouse，Ergonomic Mouse with 5 Adjustable DPI up to 7200, RGB Breathing Lights, Compatible with Laptop, Chromebook, PC, Desktop,...
8
Amazon.com
Top Pick
This is the product that stood out most — for performance, price, and overall value.
TRELC Gaming Mouse with 5 D Rocker, Ergonomic Mouse with 10000 DPI/11 Programmable Buttons, Vertical Gaming Mice Wired for PC/Laptop/E-Sports/Gamer (Black)
$28.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | ff-maus |
| Model | ffa9f2bc-df4c-43d8-b09b-b9ba1c59d13a |
| Color | Black |
- 【Ergonomic Vertical Mouse】This vertical mouse bases on ergonomics, effectively reducing user’s wrist strain and muscle pain by a natural handshake griping way. An optimal healer for wrist pain, shoulder fatigue, Carpal Tunnel Syndrome and tendinitis.
- 【5 Direction Rocker】An integrated 5 orientations rocker helps gamer to achieve their best performance in each campaign. In this gaming mouse, 1 rocker equals 5 keys. Thumb control, the realization of "front, rear, left, right, down pressure" operation. Adapted to FPS, MOBA, MMO and other different types of games.
- 【Programmable Buttons】 Intelligent macro defines function allows users to customize all 11 buttons according to different individualities. Via attached software(please refer to manual), build a professional gaming mouse for you own. Programmable data will be saved in the mouse, if plug it into a new computer there is no reset hassle.
- 【High Configuration】5 level DPI varying velocity from 1500 to 10000 sensor. This gaming mouse also adapted PMW3325 photoelectric chip, with 100IPS movement speed, 20G Acceleration, 5000FPS scanning frequency for achieving your superior gameplay.
- 【Preset RGB Led Light】RGB color-changing lamp belt is set on both sides. Customize the RGB light by neon, Marquee or Streamer effects (total 5 lighting effects) to increase the game atmosphere.
Top Picks Compared
Here are the other options we recommend. Each brings something different to the table, depending on what you’re looking for.
TRELC Gaming Mouse with 5 D Rocker, Ergonomic Mouse with 10000 DPI/11 Programmable Buttons, Vertical Gaming Mice Wired for PC/Laptop/E-Sports/Gamer (Black)
$28.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | ff-maus |
| Model | ffa9f2bc-df4c-43d8-b09b-b9ba1c59d13a |
| Color | Black |
- 【Ergonomic Vertical Mouse】This vertical mouse bases on ergonomics, effectively reducing user’s wrist strain and muscle pain by a natural handshake griping way. An optimal healer for wrist pain, shoulder fatigue, Carpal Tunnel Syndrome and tendinitis.
- 【5 Direction Rocker】An integrated 5 orientations rocker helps gamer to achieve their best performance in each campaign. In this gaming mouse, 1 rocker equals 5 keys. Thumb control, the realization of "front, rear, left, right, down pressure" operation. Adapted to FPS, MOBA, MMO and other different types of games.
- 【Programmable Buttons】 Intelligent macro defines function allows users to customize all 11 buttons according to different individualities. Via attached software(please refer to manual), build a professional gaming mouse for you own. Programmable data will be saved in the mouse, if plug it into a new computer there is no reset hassle.
- 【High Configuration】5 level DPI varying velocity from 1500 to 10000 sensor. This gaming mouse also adapted PMW3325 photoelectric chip, with 100IPS movement speed, 20G Acceleration, 5000FPS scanning frequency for achieving your superior gameplay.
- 【Preset RGB Led Light】RGB color-changing lamp belt is set on both sides. Customize the RGB light by neon, Marquee or Streamer effects (total 5 lighting effects) to increase the game atmosphere.
Nulea M504 Wired Vertical Mouse, USB Ergonomic Optical Mouse with 4 Adjustable DPI, 11 RGB Backlight Modes, Compatible for Laptop, PC, Desktop, Mac, Grey
$17.99
$19.99
PRIMEPRIME
in stock
Amazon.com
Features
| Model | M504 |
| Warranty | 2 years |
| Color | A-Grey |
| Is Adult Product |
- Advanced Ergonomic Design: Designed as 57 degree natural grip and keep your forearm muscle under natural position, making movement smoother and more flexible, reducing arm discomfort and effectively relieving wrist pain. Compared with traditional mouse, with unique ergonomic vertical mouse design, it may take a few days to get used to using it.
- 4 Adjustable DPI: Switch between DPI levels 800, 1200, 2400 and 3200 to adjust mouse responsiveness depending on your need and preference. Such as browsing the website, editing a diagram, drawing a picture, etc.
- Plug and Play: The computer mouse no drivers required, plug and play wired mouse with 5.9ft cable and USB 2.0 interface, easily accessible with standard setup features. Portable and lightweight, very easy to carry and store. The lightweight design of the mouse helps to improve posture, reduce pressure on wrists and muscles, and bring you a more comfortable office experience.
- 11 RGB Lighting: The ergonomic mouse features RGB lighting that illuminates the outline of the mouse. Users can adjust the underglow depending on their preference to add a different working experience.
- Featured Buttons: All buttons are easy to operate and won't twist your fingers. The Forward and Backward buttons are in an exact place and will help you greatly improve your efficiency. The button power is light and easy to click. Plus, metal non-slip scroll offers great durable quality. Note: Forward and Backward buttons are not compatible with MAC OS. All the buttons are non-programmable.
AooKoNi Wireless Gaming Mouse，Ergonomic Mouse with 5 Adjustable DPI up to 7200, RGB Breathing Lights, Compatible with Laptop, Chromebook, PC, Desktop, Mac,...
$5.99
$9.99
PRIMEPRIME
in stock
Amazon.com
Features
| Model | wf-05x |
| Warranty | 2 Year Manufacturer |
| Color | Black |
- 【2025 Version and 7 Programmable Buttons】We have completely upgraded the gaming mouse and added a driver. Now it has 7 programmable buttons. Users can set the mouse buttons, DPl mode, refresh rate, RGB lighting effects, etc., which greatly meets the personalized needs of gaming enthusiasts!
- 【Create your own gaming mouse lighting effect】This gaming mouse features 6 adjustable RGB backlighting modes (rainbow movement, single color, rainbow fixed, neon color, rainbow flashing, color fixed). In addition, you can also adjust the brightness and speed of the lights to create a beautiful gaming environment and illuminate your gaming atmosphere.
- 【Comfortable design and long service life】This wireless gaming mouse is designed with ergonomics, featuring a skin-friendly material. Even after long-term use, you won't feel tired or painful. It adopts a microswitch design, which is not prone to aging and can last up to 8 billion clicks!
- 【DPI Switch】This Gaming Mouse offers 3 adjustable DPI levels up to 1600, delivering precise tracking for gaming and design on any surface. Built with over 3 million-click durability for long-lasting performance
- 【Universal Compatibility】Universally compatible with Windows XP-11, MacOS, and more, this mouse offers plug-and-play convenience for laptops, desktops, and notebooks.
Redragon M602 Griffin RGB Gaming Mouse, RGB Spectrum Backlit Ergonomic Mouse with 7 Programmable Backlight Modes up to 7200 DPI for Windows PC Gamers (Black,...
$29.99
PRIMEPRIME
in stock
Amazon.com
Features
| Part Number | M602-KS |
| Model | M602-KS |
| Color | Black |
| Size | M602-KS |
- 【Fully Programmable Gaming Mouse】- Redragon Wireless Gaming Mouse All buttons can be programmed with the driver and support macro editing. You can remap the buttons, assignment of complex macro functions, change RGB backlit effects, and adjust DPI (250-8000) to fit your different needs
- 【Enhance Your Gaming Immersion】UP to 9 RGB light effects can be chosen, you also can adjust backlit effects with 16.8 million color combinations by drivers to create your fancy gaming environment, and match your game style and desktop layout
- 【High-Precision Gaming Mouse】-The wireless mouse features adjustable DPI(250-8000) and 4 adjustable polling rates ( 125Hz/250Hz/500Hz/1000Hz), you can easily adjust the moving speed, and experience a smooth, fast response and accurate tracking gaming experience
- 【Powerful Battery Life】The rechargeable mouse has a long battery life between 35 hours (RGB on) and 70 hours (RGB off) on a single charge, providing you with nonstopping use. It will auto-sleep after 1 minute of inactivity for power saving. The wireless mouse gaming also can be used while charging
- 【Extreme Ergonomics】The mouse gaming with an ergonomic design and Skin-friendly material will provide you with a comfortable grip and soft touch, Effectively relieving fatigue during long-time gaming
mobiproduct Wireless Gaming Mouse，Ergonomic Mouse with 5 Adjustable DPI up to 7200, RGB Breathing Lights, Compatible with Laptop, Chromebook, PC, Desktop,...
$5.99
PRIMEPRIME
in stock
Amazon.com
Features
| Warranty | 1 Year |
| Color | White |
- 【Brand-new Upgraded Design】The AooKoNi gaming mouse features a brand-new thumb rest design developed this year. This design is intended to prevent accidental side button presses and reduce thumb pressure, making it more ergonomic. It helps gamers operate more smoothly and is their best helper!
- 【Create your own gaming mouse lighting effect】This gaming mouse features 6 adjustable RGB backlighting modes (rainbow flow, single color, rainbow fixed, neon color, rainbow flashing, color fixed). Additionally, the included software allows you to customize the brightness and speed of the lights, creating a beautiful gaming environment and enhancing the atmosphere of your gaming session.
- 【Comfortable design and long service life】This wireless gaming mouse is designed with ergonomics, featuring a skin-friendly material. Even after long-term use, you won't feel tired or painful. It adopts a microswitch design, which is not prone to aging and can last up to 8 billion clicks!
- 【DPI Switch】This Gaming Mouse offers 5 adjustable DPI levels up to 7200, delivering precise tracking for gaming and design on any surface. Built with over 3 million-click durability for long-lasting performance
- 【Universal Compatibility】Universally compatible with Windows XP-11, MacOS, and more, this mouse offers plug-and-play convenience for laptops, desktops, and notebooks.
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