Top 5 Best Ergonomic Mice with Easy-to-Clean Surfaces

If you’re shopping for a this year, it helps to know what actually stands out.

After reviewing a wide range of options, some clear standouts emerged.

One came out ahead.

1
TECKNET Ergonomic Mouse, 4800 DPI 5 Adjustable DPI Levels, Wireless Vertical Mouse, 6 Buttons, 2.4G Silent Mouse for Laptop, PC, Chromebook, Mac - Black
TECKNET Ergonomic Mouse, 4800 DPI 5 Adjustable DPI Levels, Wireless Vertical Mouse, 6 Buttons, 2.4G Silent Mouse for Laptop, PC, Chromebook, Mac - Black
9.6
Amazon.com
2
Microsoft Arc Mouse - Black. Sleek,Ergonomic design, Ultra slim and lightweight, Bluetooth Mouse for PC/Laptop,Desktop works with Windows/Mac computers
Microsoft Arc Mouse - Black. Sleek,Ergonomic design, Ultra slim and lightweight, Bluetooth Mouse for PC/Laptop,Desktop works with Windows/Mac computers
9.5
Amazon.com
3
Nulea M501 Wireless Trackball Mouse, Rechargeable Ergonomic, Easy Thumb Control, Precise & Smooth Tracking, 3 Device Connection (Bluetooth or USB Receiver), Compatible for PC, Laptop, Mac, Windows.
Nulea M501 Wireless Trackball Mouse, Rechargeable Ergonomic, Easy Thumb Control, Precise & Smooth Tracking, 3 Device Connection (Bluetooth or USB Receiver),...
9
Amazon.com
4
Incase Bluetooth Ergonomic Mouse – Designed by Microsoft – Two Thumb Buttons, Easy to Grip Thumb Rest, Precision Tracking, Connects 3 Devices, 15 Month Battery Life, PCs/Laptops (Glacier)
Incase Bluetooth Ergonomic Mouse – Designed by Microsoft – Two Thumb Buttons, Easy to Grip Thumb Rest, Precision Tracking, Connects 3 Devices, 15 Month...
8.8
Amazon.com
5
Ai5G Wired Vertical Mouse Adjustable DPI Laptop Desktop Computer Mouse Optical Mice (for Right Hand)
Ai5G Wired Vertical Mouse Adjustable DPI Laptop Desktop Computer Mouse Optical Mice (for Right Hand)
8.5
Amazon.com

Top Pick

This is the product that stood out most — for performance, price, and overall value.

TECKNET Ergonomic Mouse, 4800 DPI 5 Adjustable DPI Levels, Wireless Vertical Mouse, 6 Buttons, 2.4G Silent Mouse for Laptop, PC, Chromebook, Mac - Black

$19.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 26, 2025 9:50 am

Features

Warranty 18 Months
Color Black
  • 【Ergonomic Design】Ergonomic mouse with Ergonomic Design, 52°angle to the tabletop. A natural handshake position effectively relieves pressure on the wrist and arm, preventing RSI syndrome caused by long-term mouse use. It is the ideal choice for prolonged office work
  • 【4800 High DPI】5 adjustable DPI settings: 4800/3200/2400/1600/800, catering to different usage habits. Even if you're new to it, you can easily master the mouse. TECKNET ergonomic wireless mouse optical tracking provides the smoothest and most precise cursor control on most surfaces
  • 【Comfortable Shape for Small/Medium Hands】The shape is rounded and comfortable with no sharp corners. Unlike other mice, this mouse is more suitable for small/medium hands, bringing a comfortable using experience and slowing down wrist fatigue. Product size: 4.13in*2.55in
  • 【Quick Click Buttons】The vertical mouse wireless added forward/back buttons provide convenience for web browsing. (Side buttons not supported on MAC OS).The features a silent click design, reducing click noise by over 99%, while ensuring optimal performance. This means you can feel every click but hardly hear any sound (note: forward/back buttons are not silent)
  • 【Stable Wireless Connection】The ergonomic mouse wireless uses 2.4GHz wireless technology, providing a stable and accurate connection without the need for any drivers. Simply plug the USB receiver into your laptop to start using the mouse, with a connection range of up to 32ft
  • 【Wide Compatibility】The mouse ergonomic is compatible with a wide range of devices and can be used on desktops, laptops, PCs, MacBooks and other devices. Works with Windows 11/10/8/7/XP and Mac OS X10.4. It has a silent feature that allows it to be used in libraries, homes, offices, and other situations where low sound levels are required

Other Options That Stood Out

Here are the other options we recommend. Each brings something different to the table, depending on what you’re looking for.

TECKNET Ergonomic Mouse, 4800 DPI 5 Adjustable DPI Levels, Wireless Vertical Mouse, 6 Buttons, 2.4G Silent Mouse for Laptop, PC, Chromebook, Mac - Black

$19.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 26, 2025 9:50 am

Features

Warranty 18 Months
Color Black
  • 【Ergonomic Design】Ergonomic mouse with Ergonomic Design, 52°angle to the tabletop. A natural handshake position effectively relieves pressure on the wrist and arm, preventing RSI syndrome caused by long-term mouse use. It is the ideal choice for prolonged office work
  • 【4800 High DPI】5 adjustable DPI settings: 4800/3200/2400/1600/800, catering to different usage habits. Even if you're new to it, you can easily master the mouse. TECKNET ergonomic wireless mouse optical tracking provides the smoothest and most precise cursor control on most surfaces
  • 【Comfortable Shape for Small/Medium Hands】The shape is rounded and comfortable with no sharp corners. Unlike other mice, this mouse is more suitable for small/medium hands, bringing a comfortable using experience and slowing down wrist fatigue. Product size: 4.13in*2.55in
  • 【Quick Click Buttons】The vertical mouse wireless added forward/back buttons provide convenience for web browsing. (Side buttons not supported on MAC OS).The features a silent click design, reducing click noise by over 99%, while ensuring optimal performance. This means you can feel every click but hardly hear any sound (note: forward/back buttons are not silent)
  • 【Stable Wireless Connection】The ergonomic mouse wireless uses 2.4GHz wireless technology, providing a stable and accurate connection without the need for any drivers. Simply plug the USB receiver into your laptop to start using the mouse, with a connection range of up to 32ft
  • 【Wide Compatibility】The mouse ergonomic is compatible with a wide range of devices and can be used on desktops, laptops, PCs, MacBooks and other devices. Works with Windows 11/10/8/7/XP and Mac OS X10.4. It has a silent feature that allows it to be used in libraries, homes, offices, and other situations where low sound levels are required

Microsoft Arc Mouse - Black. Sleek,Ergonomic design, Ultra slim and lightweight, Bluetooth Mouse for PC/Laptop,Desktop works with Windows/Mac computers

$89.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 26, 2025 9:50 am

Features

Part Number ELG-00001
Model ELG-00001
Warranty 1-year
Color Black
Release Date 2017-06-15T00:00:01Z
  • Ultra slim and lightweight. Battery life: Up to 6 months
  • Snaps flat and slips easily into a pocket or bag
  • Innovative full scroll plane lets you scroll both vertically. Wireless range: 32.8 feet (10 meters) in open area, and 16.4 feet (5 meters) in office environment
  • Dimensions: 5.17 x 2.17 x 0.56 inches. Weight: 2.91 ounces (including batteries). Battery: 2 AAA alkaline batteries (included). Battery life Up to 6 months
  • Compatibility: Microsoft Windows 10 / 8.1 / 8. Must be Bluetooth 4.0 enabled. Wireless frequency 2.4 GHz frequency range. PC must meet these requirements to download: Microsoft Windows 11 Home/Pro / 10 / 8.1 / 8, 150MB available hard disk space.

Nulea M501 Wireless Trackball Mouse, Rechargeable Ergonomic, Easy Thumb Control, Precise & Smooth Tracking, 3 Device Connection (Bluetooth or USB Receiver),...

$33.99 $35.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 26, 2025 9:50 am

Features

Part Number M501
Model M501
Warranty 18 month
Color A-Red
  • Ergonomic Design with Smooth Thumb Control: Move your cursor by the smooth trackball instead of moving your wrist and arm. Let the easy and smooth thumb control help you reduce your muscle stress. The optimal angle of the trackball mouse allows you to keep your palm in a natural position for all-day comfort.
  • Precise Tracking with Adjustable DPI: Nulea trackball mouse provides precise cursor movement for exceptional accuracy and control. With the smooth trackball, you can be more productive on the move on almost any surface, any workplace. Especially on the narrow space, such as the messy desktop, couch, bed, small writing board on a chair, etc.
  • True Wireless Freedom: Connect up to 3 devices by either bluetooth or USB dongle. Switch easily between them by the button on the bottom to improve your efficiency.[KINDLY REMINDER: The 2.4G USB receiver is stored at the bottom of the wireless trackball mouse.]
  • Rechargeable Battery: (For your best experience, please fully charge the bluetooth trackball mouse before your first use) The built-in rechargeable battery has a long battery life enables you to say goodbye to dry cell batteries. Please Note: 1. Please use our included charging cable to charge the wireless trackball mouse 2. Do not use a fast charger to charge the trackball mouse. (Directly use the computer USB port or a 5V charger to charge the bluetooth trackball mouse).
  • 6 Button High Performance: Nulea trackball mouse bluetooth is designed with thoughtful ergonomic details and an elegant curved shape. Plus the back and forward button, you can operate easily with higher productivity as well as added comfort. Note: All buttons on this wireless trackball mouse are not programmable!

Incase Bluetooth Ergonomic Mouse – Designed by Microsoft – Two Thumb Buttons, Easy to Grip Thumb Rest, Precision Tracking, Connects 3 Devices, 15 Month...

$49.99 $59.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 26, 2025 9:50 am

Features

Model 222-00001
Warranty 1 Year
Color Glacier
  • Ergonomic All-Day Comfort: Designed by Microsoft, this mouse promotes a neutral hand position with an ergonomic design and easy-to-grip thumb rest, ensuring comfort throughout the day.
  • Premium Navigation: Navigate effortlessly with a machined aluminum scroll wheel, Teflon base, and precision tracking sensor optimized for various surfaces.
  • Long Battery Life: Enjoy up to 15 months of battery life, providing reliable performance without frequent battery changes.
  • Multi-Device Connectivity: Connect up to three devices and switch seamlessly between them, enhancing your productivity and convenience.
  • Stylish and Functional: Available in three colors to match your style, this mouse also features two programmable buttons for customized functionality, backed by a 1-year limited warranty.

Ai5G Wired Vertical Mouse Adjustable DPI Laptop Desktop Computer Mouse Optical Mice (for Right Hand)

$14.98
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 26, 2025 9:50 am

Features

Part Number AI1411B
Model AI1411B
Warranty 1 year
Color for Right Hand
  • 1. Ergonomic Design: The unique, upright and ergonomically superior design of the Wired Vertical Mouse reduces harmful arm and wrist tension by allowing your hand to operate the mouse while remaining in its natural position
  • 2. Adjustable DPI settings: The Wired Vertical Mouse comes with adjustable DPI settings which allow you to control the sensitivity of the mouse cursor on screen
  • 3. Improved Accuracy: The Wired Vertical Mouse was designed to better fit the contours of the hand----significantly improving accuracy and overall comfort.
  • 4. ENCOURAGE YOUR OFFICE ENDURANCE: For those who spend most days in front of a computer, this mouse is meant for you. The Vertical Mouse’s ergonomic design promotes healthy natural hand positioning and the ultimate comfort without the need to twist your arm in an unnatural way (leading to long-term pain). From this new comfortably positioning, you can work for more hours – and be more successful at your job
  • 5. REDUCE TENSION AND ALLEVIATE PAIN: Our mouse, which is built for right-handed users, reduces muscle strain and can even undo the damage that years of using a traditional computer mouse causes. Wrist pain, shoulder fatigue, Carpal Tunnel Syndrome and Tendonitis can all be alleviated or, in many cases, eliminated with regular use

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