Best Ergonomic Mice for Repetitive Strain Injury (RSI)

If you’re shopping for a this year, it helps to know what actually stands out.

After reviewing a wide range of options, some clear standouts emerged.

Our top choice was clear.

1
Logitech MX Vertical Wireless Mouse – Ergonomic Design Reduces Muscle Strain, Move Content Between 3 Windows and Apple Computers, Rechargeable, Graphite
Logitech MX Vertical Wireless Mouse – Ergonomic Design Reduces Muscle Strain, Move Content Between 3 Windows and Apple Computers, Rechargeable, Graphite
9.8
Amazon.com
2
BraceAbility Gaming Wrist Brace - Video Game Support Guard for Console, Laptop, or PC Computer Keyboard and Mouse Gamer with Repetitive Strain Injury (RSI) Pain or Carpal Tunnel Syndrome (Left Hand)
BraceAbility Gaming Wrist Brace - Video Game Support Guard for Console, Laptop, or PC Computer Keyboard and Mouse Gamer with Repetitive Strain Injury (RSI)...
9.3
Amazon.com
3
Perixx Perimice-513L Wired Vertical Ergonomic Mouse with 2 DPI, 6 Button Optical Ergo Mouse with 2 Level DPI Switch 1000 1600, Left Handed, Black
Perixx Perimice-513L Wired Vertical Ergonomic Mouse with 2 DPI, 6 Button Optical Ergo Mouse with 2 Level DPI Switch 1000 1600, Left Handed, Black
9
Amazon.com
4
Posturite Penguin Ambidextrous Wireless Ergonomic Mouse Rechargeable, Alleviates RSI, Easy-Glide, Vertical Design, PC Computer & Apple Mac Compatible (Black/Silver, Size: Small)
Posturite Penguin Ambidextrous Wireless Ergonomic Mouse Rechargeable, Alleviates RSI, Easy-Glide, Vertical Design, PC Computer & Apple Mac Compatible...
9
Amazon.com
5
ProtoArc Ergonomic Mouse, EM11 NL Bluetooth Rechargeable Wireless Vertical Mouse, 3 Multi-Device Connectivity for Computer/PC/Laptop, 2.4GHz Optical Mice for Windows, Mac OS, Black
ProtoArc Ergonomic Mouse, EM11 NL Bluetooth Rechargeable Wireless Vertical Mouse, 3 Multi-Device Connectivity for Computer/PC/Laptop, 2.4GHz Optical Mice for...
8.6
Amazon.com

Top Pick

This is the product that stood out most — for performance, price, and overall value.

Logitech MX Vertical Wireless Mouse – Ergonomic Design Reduces Muscle Strain, Move Content Between 3 Windows and Apple Computers, Rechargeable, Graphite

$99.90 $119.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 19, 2025 10:55 pm

Features

Part Number 910-005447
Model 910-005447
Warranty Manufacturer’s warranty can be requested from customer service.
Color GRAPHITE
Release Date 2018-08-20T00:00:01Z
Size Mouse for Medium-Large Hands
  • Logitech MX Vertical Wireless Ergonomic Mouse is a great fit for medium to large size right hands
  • NATURAL HANDSHAKE POSITION: MX Vertical’s natural handshake position reduces muscular activity by 10 percent compared to a standard mouse – without any loss in overall performance
  • 57° VERTICAL ANGLE FOR IMPROVED WRIST POSTURE: MX Vertical’s unique 57° vertical angle reduces the pressure on your wrist, while your thumb is positioned comfortably on the thumb rest
  • USER TESTED. ERGONOMIST-APPROVED: MX Vertical has been designed and tested with criteria set out by leading ergonomists – improve posture, lower muscle strain, and reduce wrist pressure
  • ADVANCED OPTICAL TRACKING WITH CURSOR SPEED SWITCH: The 4000 DPI high-precision sensor results in 4x less hand movement and reduces fatigue. The cursor speed switch instantly adjusts DPI speed and accuracy with the touch of a button
  • COMFORT FORM WITH TEXTURED SURFACE: MX Vertical is shaped for the human hand and smooth to the touch. Its unique form fits a variety of hand shapes and sizes, and the textured rubber surface assures a natural grip
  • Uses FSC-certified paper for responsible packaging

Top Picks Compared

Here are the other options we recommend. Each brings something different to the table, depending on what you’re looking for.

Logitech MX Vertical Wireless Mouse – Ergonomic Design Reduces Muscle Strain, Move Content Between 3 Windows and Apple Computers, Rechargeable, Graphite

$99.90 $119.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 19, 2025 10:55 pm

Features

Part Number 910-005447
Model 910-005447
Warranty Manufacturer’s warranty can be requested from customer service.
Color GRAPHITE
Release Date 2018-08-20T00:00:01Z
Size Mouse for Medium-Large Hands
  • Logitech MX Vertical Wireless Ergonomic Mouse is a great fit for medium to large size right hands
  • NATURAL HANDSHAKE POSITION: MX Vertical’s natural handshake position reduces muscular activity by 10 percent compared to a standard mouse – without any loss in overall performance
  • 57° VERTICAL ANGLE FOR IMPROVED WRIST POSTURE: MX Vertical’s unique 57° vertical angle reduces the pressure on your wrist, while your thumb is positioned comfortably on the thumb rest
  • USER TESTED. ERGONOMIST-APPROVED: MX Vertical has been designed and tested with criteria set out by leading ergonomists – improve posture, lower muscle strain, and reduce wrist pressure
  • ADVANCED OPTICAL TRACKING WITH CURSOR SPEED SWITCH: The 4000 DPI high-precision sensor results in 4x less hand movement and reduces fatigue. The cursor speed switch instantly adjusts DPI speed and accuracy with the touch of a button
  • COMFORT FORM WITH TEXTURED SURFACE: MX Vertical is shaped for the human hand and smooth to the touch. Its unique form fits a variety of hand shapes and sizes, and the textured rubber surface assures a natural grip
  • Uses FSC-certified paper for responsible packaging

BraceAbility Gaming Wrist Brace - Video Game Support Guard for Console, Laptop, or PC Computer Keyboard and Mouse Gamer with Repetitive Strain Injury (RSI)...

$24.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 19, 2025 10:55 pm

Features

Part Number 03H0901UL
Model 03H0901UL
Color Black
Is Adult Product
Size One Size
  • ONE SIZE FITS MOST - Available in a right or left version, this universal brace fits wrist circumferences from 5 to 9 inches. Perfect for a wide range of people including men, women, and some older kids.
  • STABILIZE AND PROTECT - Excellent immobilizing wrist solution for gamer wrist, carpal tunnel, RSI or repetitive stress injury, tendonitis, De Quervain’s tenosynovitis, sprains, strains, arthritis, post-cast removal, and after surgery.
  • ERGONOMIC SUPPORT - This cock-up laced splint wraps around your thumb, hand, and forearm, keeping your wrist in a neutral position to lessen stress on your carpal tunnel and tendons. Easy one-handed application.
  • ALUMINUM SPLINTS - Removable metal palmer stay is formed to minimize wrist movement without restricting finger mobility and function. The stiff dorsal stay can be repositioned as needed.
  • SLEEPING OR DAYTIME USE - Keeps your wrist immobile as you sleep at night, game, or work, speeding up your recovery. The breathable material keeps your hand and wrist cool and comfortable during extended use.

Posturite Penguin Ambidextrous Wireless Ergonomic Mouse Rechargeable, Alleviates RSI, Easy-Glide, Vertical Design, PC Computer & Apple Mac Compatible...

$89.00 $99.00
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 19, 2025 10:55 pm

Features

Part Number 9820099
Model 9820099
Color White
Size Small, Wireless
Language English
  • ADVANCED ERGONOMIC DESIGN: the Penguin Wireless Mouse features a vertical design that sets new standards of protection against a range of upper limb conditions caused by extensive computer/laptop use, such as repetitive strain injury (RSI) and carpal tunnel syndrome (CTS)
  • AMBIDEXTROUS DESIGN: allows for easy transition between right and left-handed use, avoiding exaggerated movements of the wrist joint, which can increase pressure on the soft tissues in the carpal tunnel. When using a PC, regular switching of hands throughout the day helps prevent static muscle strain (SMS) in the arm and shoulder - a major source of discomfort in mouse work
  • PRECISION PERFORMANCE: adjustable 400, 600, 800 or 1200 DPI resolution optical tracking technology encourages fast and precise operating movements on a wide range of surfaces
  • EASY-GLIDE: symmetrical base allows the user to rest either hand comfortably alongside the vertical design, encouraging the use of the bigger muscles in the fore and upper arm to maneuver the ergo mouse. Fine cursor control is achievable with small hand and/or finger movements
  • RECHARGEABLE BATTERY: up to 30 days on a single charge, depending on use - perfect for working in both home and office environments

Perixx Perimice-513L Wired Vertical Ergonomic Mouse with 2 DPI, 6 Button Optical Ergo Mouse with 2 Level DPI Switch 1000 1600, Left Handed, Black

$19.99 $21.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 19, 2025 10:55 pm

Features

Part Number 11516
Model 11516
Warranty 1 Year Limited Warranty
Color black
Release Date 2019-07-01T00:00:01Z
Size Medium
Language Italian
  • Perimice-513l is a wired ergonomic vertical mouse for left handers. It is designed for all different size of hand, fitting the natural position of palm and wrist muscle while gripping the mouse.
  • Natural ergonomic vertical with left-handed design. Recommended to repetitive strain injuries RSI user and user works particularly long periods on the computer
  • Easy access to multiple usage through 6 buttons. Instinct two-level sensitivity Adjustment of the most widely-used 1000/1600 DPI setup.
  • Plug and play mouse with USB interface, easy to start to use with standard setting function. High quality rubber coating surface
  • Compatible with Windows 7, 8, and 10; wired USB connection

ProtoArc Ergonomic Mouse, EM11 NL Bluetooth Rechargeable Wireless Vertical Mouse, 3 Multi-Device Connectivity for Computer/PC/Laptop, 2.4GHz Optical Mice for...

$26.99
PRIMEPRIME
in stock
Amazon.com
Amazon price updated: September 19, 2025 10:55 pm

Features

Part Number Protoarc B0CX18LHWS
Model EM11 NL
Warranty 2 YEAR
Color Black
Size One Size
  • Connect up to 3 Devices: This ergonomic wireless mouse features dual BT 5.0 and 2.4G USB connectivity modes for simultaneous connection of up to 3 different devices, and is compatible with Windows 8, Windows 10 or higher, Mac OS X 10.12 or higher, and Android 4.3 or higher
  • Rechargeable Ergonomic Mouse: The Bluetooth Vertical Mouse has a built-in 500mAh Li-Ion battery that can be conveniently recharged using the included Type-C cable
  • Ergonomic Vertical Design: The ergonomic mouse wireless keeps your wrist naturally straight, putting your forearm and wrist in a more natural and relaxed position, which can reduce discomfort and strain, helping to improve productivity and reduce the risk of repetitive strain injuries compared to a standard mouse. Warm tips: We encourage you to relax your palm and hold the mouse naturally when using a vertical mouse
  • Learning curve: Since it takes a learning curve to get used to the shape when using our ergonomic mouse for the first time, it may cause inconvenience to your mouse grip, We recommend that you take 1-2 weeks to get used to it, as many users find that it will help reduce the pressure and pain on your wrist caused by long-term use of the mouse and improve comfort
  • Notes: We recommend that small to medium hands use our ergonomic vertical mouse. Please measure the size before ordering for a better fit and more comfort
  • Adjustable Dpi & High Performance: 1000/1600/2400 DPI levels provide higher sensitivity than standard optical mice for precise optical tracking; with the back and forward buttons, you can easily navigate websites and increase work efficiency. Note: All buttons are not programmable and the forward and back buttons are not compatible with Mac OS systems
  • Quiet Clicking: The silent click sound of the left and right mouse buttons help you focus on your work, Note:the middle scroll wheel and and the back/forward buttons are not silent.

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Digital Wellness Labs
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